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October 2, 2025Journal of Human LactationOpen Access

Comparing Impacts of Donor Human Milk to Formula Supplementation on the Gut Microbiome of Full-Term Infants Born Via Cesarean Section: Protocol for a Pilot Randomized Controlled Trial

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Authors

MBMeredith BrockwayMKMaria KhalidYKYara Khalil

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Overview

Pilot randomized controlled trial examines donor human milk versus formula effects on gut microbiome and maternal mental health in infants.

Key Points

  • Donor human milk supplementation improves the infant gut microbiome compared to formula, impacting health outcomes positively.
  • Infant health outcomes and maternal mental health were assessed over the first 36 months postpartum for 187 full-term infants.
  • Pilot randomized controlled trial design provides essential data to inform future longitudinal studies and guidelines.
  • The study highlights the importance of exploring nutrition alternatives for infants delivered via Cesarean section.

Cite This Study

Brockway et al. (2025) studied this question.

synapsesocial.com/papers/68de79685b556a9128e1a8a4https://doi.org/10.1177/08903344251369442
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplemental Donor Milk vs Infant Formula in Moderate to Late Preterm Infants2025
  2. 2Improving immune‐related health outcomes post‐cesarean birth with a gut microbiome‐based program: A randomized controlled trial2025 · 4 citations
  3. 3Growth Efficiency of Donor Human Milk Compared With Maternal Milk and Formula in Preterm Infants2025
  4. 4Seeding and feeding: nutrition and birth-associated exposures shape gut microbiome assembly in breastfed infants2025 · 8 citations
  5. 5Comparative Analysis of Breastfeeding and Infant Formulas: Short‐ and Long‐Term Impacts on Infant Nutrition and Health2025 · 12 citations