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September 10, 2025JAMA Pediatrics

Supplemental Donor Milk vs Infant Formula in Moderate to Late Preterm Infants

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Authors

ARAlice RumboldMLMelissa LaiDADeanne August

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Overview

Randomized clinical trial compares donor milk and infant formula's impact on establishing full enteral feeds in preterm infants, suggesting minimal difference.

Key Points

  • Supplemental donor milk did not significantly reduce the time to full enteral feeds in infants.
  • The mean time to reach full enteral feeds was 5.7 days for donor milk and 5.8 days for formula, showing no distinct effect.
  • Secondary outcomes indicated similar feed intolerance and growth patterns, but donor milk infants had slower birth weight regain.
  • Infants were monitored until 6-month corrected age, providing insights on longer-term outcomes.

Cite This Study

Rumbold et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479c979https://doi.org/10.1001/jamapediatrics.2025.2365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Growth Efficiency of Donor Human Milk Compared With Maternal Milk and Formula in Preterm Infants2025
  2. 2Comparing Impacts of Donor Human Milk to Formula Supplementation on the Gut Microbiome of Full-Term Infants Born Via Cesarean Section: Protocol for a Pilot Randomized Controlled Trial2025
  3. 3An Enhanced Nutrition Bundle for Preterm Infants in Burundi: A Retrospective Observational Study2026
  4. 4Enhanced versus standard fortification of pasteurized donor human milk for growth in very low birth weight infants: a randomized controlled trial2025
  5. 5Human Milk Banking and Donor Milk: Effect on Growth and Nutrition in the NICU2025