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September 10, 2025Pediatric Allergy and ImmunologyOpen Access

Improving immune‐related health outcomes post‐cesarean birth with a gut microbiome‐based program: A randomized controlled trial

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Authors

PNPamela A. NietoCNClaudia NakamaJTJulian Trachsel

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Overview

Randomized controlled trial shows changes in gut microbiome composition and reduces atopic conditions in infants, suggesting intervention benefits.

Key Points

  • The intervention led to higher levels of Bifidobacterium in infants, indicating a positive shift in the gut microbiome.
  • Compared to controls, the intervention showed a significant reduction in atopic dermatitis prevalence among infants.
  • Personalized recommendations and educational materials contributed to the observed improvements in microbiome health.
  • A decrease in the C-section index was noted, aligning the gut microbiome composition closer to that of vaginally born infants.

Cite This Study

Nieto et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64782455https://doi.org/10.1111/pai.70182
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparing Impacts of Donor Human Milk to Formula Supplementation on the Gut Microbiome of Full-Term Infants Born Via Cesarean Section: Protocol for a Pilot Randomized Controlled Trial2025
  2. 2Impact of Perioperative Antibiotic Prophylaxis in Caesarean Section on the Maternal Gut Microbiome: A Systematic Review2025
  3. 3Gut microbiota development, antibiotic resistome, and related perinatal factors in early infancy2025
  4. 4Seeding and feeding: nutrition and birth-associated exposures shape gut microbiome assembly in breastfed infants2025 · 8 citations
  5. 5Combined Quality Management and Preventive Care in Cesarean Sections: Effects on Maternal Infection2025