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October 1, 2025MedicineOpen Access

Cholesterol-HDL-glucose index and type 2 diabetes risk in middle-aged and older adults: Evidence from a nationwide Chinese cohort

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Authors

TLTingting LiYLYuqi LiNXNana Xiang

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Overview

Cross-sectional analysis reveals cholesterol-HDL-glucose index predicts type 2 diabetes risk, suggesting its utility as a novel indicator in older populations.

Key Points

  • Each unit increase in the cholesterol-HDL-glucose index is linked to a 1.5-fold increase in type 2 diabetes risk.
  • The predictive performance of the cholesterol-HDL-glucose index shows an area under the curve of 0.825 for type 2 diabetes risk in a cohort of 8251 participants.
  • Cross-sectional analyses utilized multivariate logistic regression and ROC curve analysis to establish the relationship between cholesterol-HDL-glucose index and type 2 diabetes.
  • The cholesterol-HDL-glucose index provides a practical screening tool for early detection of type 2 diabetes among middle-aged and older adults in China.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc4991a2https://doi.org/10.1097/md.0000000000044830
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Also Consider

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  1. 1Association between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes mellitus prevalence in US adults: A cross-sectional study based on National Health and Nutrition Examination Survey 2009-2018.2025 · 12 citations
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  3. 3Evaluating the associations and predictive performance of triglyceride-glucose index and related indicators for chronic diseases in a Chinese cohort2025 · 1 citations
  4. 4High triglyceride-glucose index is associated with diabetes mellitus in people with HIV in Southwest China: a 13-year retrospective longitudinal cohort study2025 · 2 citations
  5. 5The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study2025