Dose-Response Evaluation of Blumea balsamifera Leaf Ethanol Extract in Acute and Subchronic Toxicity Models in Mice for Sustainable Application

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Dose-dependent effects of blumea balsamifera leaf ethanol extract evaluated in mice, suggesting safety at moderate levels.

High doses of blumea balsamifera leaf ethanol extract significantly reduced body weight gain in mice.
Toxicity assessments showed notable elevations in organ weights and various blood parameters at higher doses.
Assessments included acute and subchronic toxicity models, revealing dose-dependent physiological and biochemical changes.
Findings indicate that lower doses of BBEE are well tolerated and suggest its sustainable application potential.

Quan et al. (2025) studied this question.

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