September 5, 2025Deleted JournalOpen Access

Oral Acute and Sub-chronic Toxicity Assessment of Methanol and Aqueous Extracts of the Stem Bark of Bridelia exaltata (Scrub Ironbark) in Wistar Rats

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Discussion

This analysis evaluates acute and sub-chronic toxicity of bridelia exaltata extracts, highlighting possible hematological alterations.

Acute toxicity assessment showed no mortality in wistar rats, indicating an LD₅₀ greater than 6,000 mg/kg.
Sub-chronic exposure revealed significant reductions in red blood cell count, hemoglobin, and packed cell volume in high-dose groups.
Phytochemical analysis indicated high flavonoid and phenol contents in the extracts, suggesting potential health benefits.
Histopathological findings showed mild organ alterations at high doses, emphasizing the need for cautious usage.

Labaran et al. (2025) studied this question.

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