August 21, 2025Frontiers in PharmacologyOpen Access

Integrated neurobehavioral and organ-specific safety profiling of baicalin: acute/subacute toxicity studies

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Discussion

Acute toxicity of baicalin shows no mortality in mice, suggesting safety for neurodegenerative treatment.

Baicalin demonstrated high acute safety with an LD50 over 4,000 mg/kg, indicating potential as a neuroprotective agent.
Subacute toxicity revealed temporary gastrointestinal issues and some behavioral changes that resolved within 24 hours.
Assessment involved acute and subacute toxicity studies, measuring survival, behaviors, and organ function in mice.
Findings highlight potential hepatorenal toxicity with high doses, emphasizing the need for monitoring during extended use.

Yang et al. (2025) studied this question.

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