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September 26, 2025Behavior GeneticsOpen Access

Genetic Overlap Between DSM-IV Major Depressive Disorder and Suicidal Behaviors: Evidence from Polygenic Risk Scores in Young Adult Twins

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Authors

NGNathan A. GillespieMSMei-Hsin SuSLSéverine Lannoy

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Overview

This research examines genetic overlap of major depressive disorder and suicidal behaviors in young adults, indicating shared risks.

Key Points

  • High heritability estimates for suicidal behaviors range from 51 to 80%, while major depressive disorder estimates are lower at 39 to 41%.
  • Genetic correlations among suicidal thoughts and behaviors are remarkably high, with correlations ranging from 0.85 to 0.99.
  • Multivariate twin modeling reveals distinct environmental influences for major depressive disorder compared to suicidal behaviors.
  • The study supports the idea of shared genetic architecture between major depressive disorder and suicidal behaviors, emphasizing the need to address environmental factors.

Cite This Study

Gillespie et al. (2025) studied this question.

synapsesocial.com/papers/68d5e189136d0912e8f6e900https://doi.org/10.1007/s10519-025-10234-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combined family history and polygenic score prediction of major depressive disorder2025 · 1 citations
  2. 2Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up2025
  3. 3Genetic factors in the development of suicidal ideation – results of a GWAS study2025
  4. 4Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK BioBank2025 · 1 citations
  5. 5Genetic factors predicting risk of mood disorders in adolescents2025