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October 23, 2025Open Access

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK BioBank

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Authors

DSDaniel StowRTRuby S. M. TsangIKIoanna Katzourou

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Overview

Logistic regression shows combined polygenic risk scores improve understanding of genetic predisposition in multimorbidity, indicating genetic variation plays a critical role.

Key Points

  • Combining polygenic risk scores enhances variance prediction for physical-mental health multimorbidity.
  • The odds ratio for internalising traits and type 2 diabetes is 1.18 per standard deviation increase in polygenic risk score.
  • Logistic regression evaluated the polygenic risk scores in over 200,000 UK Biobank participants for accuracy.
  • This genetic risk measure might enable earlier intervention for physical-mental health multimorbidity.

Cite This Study

Stow et al. (2025) studied this question.

synapsesocial.com/papers/68f9d6583f378872224924a1https://doi.org/10.1101/2025.10.20.25338357
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The complementary roles of rare variant burden scores and common variant polygenic risk scores in genetic risk prediction of complex disorders2025
  2. 2A MULTI-TRAIT APPROACH IMPROVES POLYGENIC RISK SCORES FOR CHRONIC BACK PAIN ACROSS POPULATION-BASED AND CLINICALLY ASCERTAINED SAMPLES2025
  3. 3Within-family validation of polygenic risk scores in the UK Biobank: Investigating the role of principal component analysis and mixed model association2025
  4. 4Combined family history and polygenic score prediction of major depressive disorder2025 · 1 citations
  5. 5Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins2025