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September 25, 2025Tropical Medicine and Infectious DiseaseOpen Access

Predictors of Tuberculous Meningitis Mortality Among Persons with HIV in Mozambique

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Authors

ENEdy NacarapaIMIsabelle MunyangajuDODulce Osório

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Overview

Retrospective cohort study identifies key mortality predictors in HIV-positive individuals with TBM, suggesting urgent interventions.

Key Points

  • Mortality among PLWH diagnosed with TBM was 3.76 deaths per 100 person-months, highlighting the severity of the condition.
  • Male sex and BMI < 18.5 kg/m2 were independently associated with increased mortality, emphasizing the need for targeted care.
  • Cox proportional hazard models identified key predictors, including ART failure and high CSF opening pressure impacting survival.
  • Urgent interventions are proposed to optimize ART and manage intracranial pressure, essential for improving outcomes.

Cite This Study

Nacarapa et al. (2025) studied this question.

synapsesocial.com/papers/68d5db0cddad3c16d46378abhttps://doi.org/10.3390/tropicalmed10100276
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinico-radiological Profile of Tuberculous Meningitis and Mortality Predictors of Hospitalized Patients: An Ambi-directional Observational Study2025
  2. 2Rates and Risk Factors for On‐Treatment Mortality Among a Cohort of Adults Treated for Drug‐Sensitive Tuberculosis: Analysis of Data From the Adherence Support Coalition to End Tuberculosis Consortium in Five Countries2025
  3. 3Tuberculosis in new cases: the impact of HIV status on clinical manifestations2025
  4. 4Evaluation of Predictors of Outcome in Patients with Tubercular Meningitis2025
  5. 5Hospitalization and diabetes mellitus as predictors of unfavorable tuberculosis treatment outcomes2026