Rates and Risk Factors for On‐Treatment Mortality Among a Cohort of Adults Treated for Drug‐Sensitive Tuberculosis: Analysis of Data From the Adherence Support Coalition to End Tuberculosis Consortium in Five Countries

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Observational analysis found high tuberculosis mortality linked to HIV status and ART use in various countries, highlighting critical indicators.

Mortality rates for drug-sensitive tuberculosis ranged from 7.6 to 23.3 per 100 person-years across five countries.
Older age significantly increased mortality risk, with adjusted rate ratios from 2.38 to 6.57, across all countries.
HIV-positive status correlated with higher mortality, with rates varying by country between 1.44 and 2.98.
ART use showed a protective effect in South Africa and Ukraine, suggesting context-dependent impacts on treatment outcomes.

Tadesse et al. (2025) studied this question.

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View Full Paper

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Authors

Observational analysis found high tuberculosis mortality linked to HIV status and ART use in various countries, highlighting critical indicators.

Mortality rates for drug-sensitive tuberculosis ranged from 7.6 to 23.3 per 100 person-years across five countries.
Older age significantly increased mortality risk, with adjusted rate ratios from 2.38 to 6.57, across all countries.
HIV-positive status correlated with higher mortality, with rates varying by country between 1.44 and 2.98.
ART use showed a protective effect in South Africa and Ukraine, suggesting context-dependent impacts on treatment outcomes.

Tadesse et al. (2025) studied this question.

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