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May 13, 2026BMC Infectious DiseasesOpen Access

Hospitalization and diabetes mellitus as predictors of unfavorable tuberculosis treatment outcomes

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Authors

EMEdson Beyker de MendonçaMAMariana Araújo-PereiraRMRodrigo Carvalho de Menezes

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Overview

Retrospective cohort study identifies hospitalization and diabetes as predictors of poor TB outcomes, suggesting new risk stratification methods.

Key Points

  • This study aims to identify baseline characteristics associated with unfavorable tuberculosis treatment outcomes.
  • Retrospective cohort study of adult TB participants treated from 2015 to 2022.
  • Data collected from electronic medical records, including clinical and laboratory tests.
  • Backward stepwise multivariable regression to identify independent predictors.
  • Unfavorable outcomes were observed in 7.2% of participants (N = 35), including 1.8% deaths (N = 9) and 5.4% treatment failures (N = 26).
  • Baseline hospitalization was an independent predictor of unfavorable outcomes (aOR = 3.21, 95% CI 1.42–7.26).
  • Diabetes mellitus was also identified as a predictor of treatment failure and death (aOR = 3.04, 95% CI 1.10–8.45).

Cite This Study

Mendonça et al. (2026) studied this question.

synapsesocial.com/papers/6a04141c79e20c90b4444573https://doi.org/10.1186/s12879-026-13343-1
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