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September 25, 2025Frontiers in ImmunologyOpen Access

Multi-omics analysis of the tumor microenvironment after metastasis: advancing toward personalized immunotherapy and molecular targeted strategies

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Authors

QGQing GaoHWHaibin WuLDLi Duan

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Overview

This review summarizes findings on the tumor microenvironment in metastasis, highlighting key molecular signatures and immunotherapy implications.

Key Points

  • The metastatic tumor microenvironment influences cancer cell behavior, impacting immunotherapy effectiveness.
  • Recent advances in multi-omics technologies have enhanced understanding of the metastatic tumor microenvironment.
  • Integrating multi-omics data reveals actionable therapeutic targets within the tumor microenvironment.
  • Insights into molecular interactions drive the development of precision strategies aimed at combating therapy resistance.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd72dc445aa9033b0d66https://doi.org/10.3389/fimmu.2025.1648987
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The tumor microenvironment: a dynamic ecosystem and therapeutic nexus in modern oncology2026
  2. 2Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment2025
  3. 3The Tumor Microenvironment: Impact on Tumor Growth, Metastasis, and Therapeutic Resistance: A Systematic Review2025
  4. 4Multi-Omics Profiling Reveals the Interplay Between Genomic Instability and Microenvironmental Remodeling in Pancreatic Neuroendocrine Tumors2025
  5. 5New trend in molecular diagnostics: Insights from the tumor microenvironment2025