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September 10, 2025Molecular CancerOpen Access

Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment

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Authors

JLJiayuan LeYDYating DianDZDeze Zhao

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Overview

This review highlights tumor heterogeneity and immune escape in cancer, suggesting advances in precision oncology.

Key Points

  • Precision oncology can be enhanced through single-cell multi-omics technologies, improving treatment outcomes for cancer.
  • Recent developments in single-cell sequencing uncover immune escape and treatment resistance within heterogeneous tumors.
  • These approaches illuminate patient-specific immune responses, offering insights vital for personalizing cancer therapies.
  • Current challenges include technical limitations of single-cell technologies, which impede broader application in clinical settings.

Cite This Study

Le et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a57c8https://doi.org/10.1186/s12943-025-02426-3
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Also Consider

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  1. 1Immune profiling in oncology: bridging the gap between technology and treatment2025 · 7 citations
  2. 2Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology2025 · 1 citations
  3. 3Applications and advances of multi-omics technologies in gastrointestinal tumors2025
  4. 4Integration of multi-omics approaches in exploring intra-tumoral heterogeneity2025
  5. 5Multi-omics analysis of the tumor microenvironment after metastasis: advancing toward personalized immunotherapy and molecular targeted strategies2025