September 23, 2025Journal of Clinical MedicineOpen Access

Preoperative Opioid Use Disorder Predicts Prolonged Ventilation, Central Line Placement, and Major Anesthesiology Complications After ACDF Surgery: A Big Data Analysis of 180,000 Cases

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Authors

DMDavid Maman MNManeesh Nandakumar YSYaniv Steinfeld

Discussion

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Overview

Analysis shows that opioid use disorder significantly raises risks of prolonged ventilation and major complications in ACDF patients, suggesting urgent preoperative screening needs.

Key Points

Patients with opioid use disorder experienced nearly three times as many major anesthesiology complications compared to those without the disorder.
Prolonged ventilation occurred in 1.5% of the 178,215 patients analyzed, with OUD significantly elevating this risk to higher than 24 and 96 hours.
The cohort analysis, adjusted via propensity score matching, highlighted the economic impact with OUD patients incurring excess costs of about $855 per surgery.
The findings indicate a pressing need for systematic preoperative urine drug screening to mitigate risks associated with opioid use disorder.

Cite This Study

Maman et al. (2025) studied this question.

synapsesocial.com/papers/68d43ee5713b0b5dfea7ea33 https://doi.org/10.3390/jcm14186661

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September 23, 2025Journal of Clinical MedicineOpen Access

Preoperative Opioid Use Disorder Predicts Prolonged Ventilation, Central Line Placement, and Major Anesthesiology Complications After ACDF Surgery: A Big Data Analysis of 180,000 Cases

View Full Paper

Ask AI

Bookmark

Authors

DMDavid Maman MNManeesh Nandakumar YSYaniv Steinfeld

Discussion

Member takes

Overview

Analysis shows that opioid use disorder significantly raises risks of prolonged ventilation and major complications in ACDF patients, suggesting urgent preoperative screening needs.

Key Points

Patients with opioid use disorder experienced nearly three times as many major anesthesiology complications compared to those without the disorder.
Prolonged ventilation occurred in 1.5% of the 178,215 patients analyzed, with OUD significantly elevating this risk to higher than 24 and 96 hours.
The cohort analysis, adjusted via propensity score matching, highlighted the economic impact with OUD patients incurring excess costs of about $855 per surgery.
The findings indicate a pressing need for systematic preoperative urine drug screening to mitigate risks associated with opioid use disorder.

Cite This Study

Maman et al. (2025) studied this question.

synapsesocial.com/papers/68d43ee5713b0b5dfea7ea33 https://doi.org/10.3390/jcm14186661

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