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September 10, 2025CureusOpen Access

The Impact of Preoperative Nicotine Use in the Development of Opioid Use Disorder Following Lumbar Disc Discectomy Procedures: A National Database Study

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Authors

JHJinpyo HongPenn State Milton S. Hershey Medical CenterAKAndrew KimZFZachary Freedman

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Implication

Retrospective analysis reveals nicotine dependence increases opioid use disorder risk in patients, suggesting additional implications on postoperative outcomes.

Key Points

  • Nicotine dependence significantly raises the risk of opioid use disorder at multiple time points post-surgery.
  • Patients with preoperative nicotine dependence faced higher rates of surgical site infection and myocardial infarction after lumbar discectomy.
  • The retrospective analysis used a national database with over 18,000 matched subjects to assess outcomes linked to nicotine use.
  • Findings underline the need for patient education and smoking cessation programs to improve postoperative results.

Cite This Study

Hong et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784474https://doi.org/10.7759/cureus.91511
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