Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 23, 2025Frontiers in GeneticsOpen Access

Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma

View Full Paper
Ask AI
Bookmark
Share

Authors

JQJiaxuan QinLZLijian ZhangBCBowen Chen

Discussion

Loading...

Member takes

Overview

Systematic analysis identifies a prognostic mitochondrial gene signature in ccRCC, suggesting links to immune response.

Key Points

  • The mitochondrial-related gene signature predicts survival outcomes in patients with clear cell renal cell carcinoma.
  • High-risk ccRCC patients show worse prognosis and reduced response to immune checkpoint inhibitors.
  • Utilizing TCGA databases, this study developed a reliable predictive model using mitochondrial-related genes.
  • The findings highlight the importance of the tumor microenvironment in influencing cancer prognosis and treatment response.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/68d43ed1713b0b5dfea7e088https://doi.org/10.3389/fgene.2025.1543593
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development and validation of mitochondrial metabolism-related genes in the prognostic and immunological characterization of clear cell renal cell carcinoma2025
  2. 2A Prognostic Risk Signature Based on Myeloid-Derived Suppressor Cells and Regulatory T Cells in Clear Cell Renal Cell Carcinoma.2025
  3. 3Development of a Mitochondrial Permeability Transition‐Driven Necrosis‐Related Prognostic Signature in Cervical Cancer: Integrating Bulk Transcriptomic and Single‐Cell Data2025
  4. 4Identification of Molecular Signatures and Prognostic Markers in Clear Cell Renal Cell Carcinoma through Advanced Bioinformatics and Systems Biology2025
  5. 5Clinical value and in vitro validation of gene and molecular subtype identification in renal clear cell carcinoma2025