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August 17, 2025

Clinical value and in vitro validation of gene and molecular subtype identification in renal clear cell carcinoma

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Authors

JCJun ChenCLChang‐Jiu LiKSKun Shang

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Overview

Analysis reveals prognostic indicators in clear cell renal cell carcinoma, highlighting gene expression and immune response.

Key Points

  • The analysis identifies seven genes linked to clear cell renal cell carcinoma (ccRCC) prognosis, significantly impacting survival rates.
  • Prognostic framework shows areas under the receiver operating characteristic curves of 0.88, 0.82, and 0.81 for 1, 3, and 5 years respectively.
  • Utilizing transcriptome data from TCGA-KIRC and GEO cohorts, the study employs nonnegative matrix factorization to create molecular subgroups.
  • The model enhances ccRCC management by evaluating immune response and chemotherapy sensitivity, indicating potential for individualized treatments.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68a3532c234c60ad5c20e5f8https://doi.org/10.21203/rs.3.rs-6872158/v1
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