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November 28, 2025Clinical and Experimental MedicineOpen Access

Development and validation of mitochondrial metabolism-related genes in the prognostic and immunological characterization of clear cell renal cell carcinoma

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Authors

LLLipeng LuJJJianbin JinDLDan Lu

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Overview

Analysis identifies biomarkers and immune characteristics in ccRCC, suggesting mitochondrial metabolism links to patient prognosis.

Key Points

  • Prognostic model predicts ccRCC patients' outcomes based on mitochondrial metabolism-related biomarkers.
  • Key findings include distinct molecular subtypes and elevated regulatory T cells in high-risk patients.
  • Analysis utilized transcriptomic data and consensus clustering analysis to explore ccRCC immune characteristics.
  • Identifying the Wnt signaling pathway helps highlight important biological processes in ccRCC progression.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/6928f0f9a65b730b9ea79816https://doi.org/10.1007/s10238-025-01966-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma2025
  2. 2Identification of Molecular Signatures and Prognostic Markers in Clear Cell Renal Cell Carcinoma through Advanced Bioinformatics and Systems Biology2025
  3. 3Clinical value and in vitro validation of gene and molecular subtype identification in renal clear cell carcinoma2025
  4. 4Comprehensive analysis of metabolic patterns in renal cell carcinoma: implications for prognosis and treatment2025 · 1 citations
  5. 5Comprehensive investigation of a new signature integrating lipid metabolism and immune-related genes for clear cell renal cell carcinoma prognosis and immunometabolism landscapes2025