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October 2, 2025Annual Review of Cell and Developmental BiologyOpen Access

Regulation of Hematopoietic Stem Cell Dormancy and Quiescence: Insights into Regeneration and Disease

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Authors

JRJasmin RettkowskiNCNina Cabezas‐Wallscheid

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Overview

Exploration of how quiescence and dormancy of hematopoietic stem cells regulate regeneration, indicating potential links to disease.

Key Points

  • Dysregulation of hematopoietic stem cells can lead to complications in regeneration and disease.
  • Hematopoietic stem cells maintain their potential through quiescence and dormancy, which are essential properties for self-renewal.
  • Factors like aging and inflammation disrupt the quiescent state of hematopoietic stem cells, leading to adverse outcomes.
  • Research delves into mechanisms of stem cell dormancy to find insights into their regulation under stress conditions.

Cite This Study

Rettkowski et al. (2025) studied this question.

synapsesocial.com/papers/68de5da283cbc991d0a206dbhttps://doi.org/10.1146/annurev-cellbio-101323-023806
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