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August 12, 2025Cell ReportsOpen Access

Host and environmental determinants of human milk oligosaccharides and microbiota in the Lifelines NEXT cohort

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Authors

JSJohanne E. SpreckelsAKAlexander KurilshikovAFAsier Fernández-Pato

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Overview

Analysis of maternal and environmental factors shaping milk composition and gut bacteria in infants, indicating complex interactions.

Key Points

  • HMOs and milk microbiota are influenced by maternal genetics and environmental factors, showing distinct patterns over lactation.
  • In a cohort of 524 mothers, specific HMOs were linked to variations in infant fecal microbiota, emphasizing their importance in development.
  • This study involves 1,542 milk samples and examines how feeding practices affect the milk microbiota and its consistency across pregnancies.
  • Stability of HMOs and microbiota across multiple pregnancies suggests long-term maternal influences on infant health and gut development.

Cite This Study

Spreckels et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d6477127dhttps://doi.org/10.1016/j.celrep.2025.116124
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