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October 2, 2025Combinatorial Chemistry & High Throughput Screening

Shen-Ling-Bai-Zhu-San Mitigates Ulcerative Colitis by Enhancing Intestinal Barrier Integrity via the AhR-CYP1A1-NF-κB Signal Pathway

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Authors

LMLan MingNanjing University of Chinese MedicineJCJie ChenNorth Sichuan Medical UniversityJMJing MaShanghai Medical College of Fudan University

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Overview

Observational analysis reveals Shen-Ling-Bai-Zhu-San improves ulcerative colitis symptoms in mice, suggesting a role for AhR and NF-κB pathways.

Key Points

  • SLBZS significantly improved symptoms of ulcerative colitis, including body weight and colon length.
  • Molecular docking revealed strong interactions between bioactive compounds and ulcerative colitis-related targets.
  • UPLC-QE-MS analysis identified 458 constituents of SLBZS, highlighting its complex composition and multi-target potential.
  • Restoration of tight junction proteins Occludin and Claudin-1 points to the strengthening of the intestinal barrier.

Cite This Study

Ming et al. (2025) studied this question.

synapsesocial.com/papers/68de68ea83cbc991d0a21337https://doi.org/10.2174/0113862073425771250828112001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigating the Therapeutic Mechanisms of Shen-Ling-Bai-Zhu-San in Type 2 Diabetes and Ulcerative Colitis Comorbidity: A Network Pharmacology and Molecular Simulation Approach2025
  2. 2Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function2025 · 4 citations
  3. 3Zanthoxylum Nitidum Ameliorates Intestinal Barrier Dysfunction and Inflammation in TNBS ‐Induced Colitis Rats and LPS ‐Stimulated Caco‐2 Cells2025 · 6 citations
  4. 4Banxia Xiexin Decoction Ameliorates Ulcerative Colitis via a Flora‐Metabolite‐Inflammation Axis Through Integrated Metabolomic and Microbiome Analysis2025 · 1 citations
  5. 5Lobetyolin ameliorates DSS-induced ulcerative colitis in mice by alleviating inflammation, restoring barrier function, and modulating gut microbiota–metabolite interactions2025 · 3 citations