September 19, 2025Endocrine ConnectionsOpen Access

Shared Molecular Mechanisms Between Type 2 Diabetes and Thyroid Cancer: Integrated Bioinformatics Insights for Prognostic Biomarker Discovery

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Twenty-eight shared differentially expressed genes were identified between type 2 diabetes and thyroid cancer, highlighting genetic overlap.
Cox regression analyses established a risk model with seven genes effectively stratifying thyroid cancer patients into distinct survival groups.
Functional enrichment analyses underscored key biological pathways like NF-kB signaling and extracellular matrix remodeling.
The study indicates that PRDM1 and ZFPM2 may serve as therapeutic targets for thyroid cancer patients with concurrent diabetes.

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Integration of bioinformatics reveals shared pathways in type 2 diabetes and thyroid cancer, suggesting potential biomarkers.

Qi et al. (2025) studied this question.

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