August 20, 2025PLoS ONEOpen Access

Common molecular links and therapeutic insights between type 2 diabetes and kidney cancer

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Seventy-four shared DEGs distinguish both kidney cancer and type 2 diabetes patients from controls, providing insights into their shared pathogenesis.
Top-ranked shared key genes include CD74 and JUN, which are linked to pathways like NF-κB signaling and apoptosis.
An integrated bioinformatics approach was used to analyze differential expression patterns and construct a protein-protein interaction network.
Findings suggest potential therapeutic drugs, including Imatinib and Sorafenib, that can target shared mechanisms in kidney cancer and type 2 diabetes.

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Bioinformatics analysis identifies shared genes and potential therapies for type 2 diabetes and kidney cancer.

Ahmmed et al. (2025) studied this question.

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