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September 10, 2025Frontiers in ImmunologyOpen Access

A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease

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Authors

THTingting HuDXDuan Xiao-meiJGJiale Gao

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Overview

This analysis identifies shared biomarkers in type 2 diabetes mellitus and COPD, suggesting T-cell pathways' role.

Key Points

  • Eight diagnostic markers were confirmed through machine learning, with SUMF2 being significantly associated with T2DM and COPD in T-cell subsets.
  • A total of 738 DEGs for T2DM and 1391 for COPD were identified, with key genes enriched in immune-related pathways.
  • Microarray data analyzed revealed shared diagnostic markers through validation with human blood PBMC samples from various groups.
  • The T-cell pathway's involvement in T2DM and COPD highlights SUMF2 as a potential diagnostic marker for both diseases.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479c3e9https://doi.org/10.3389/fimmu.2025.1536551
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