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September 18, 2025PLoS ONEOpen Access

TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration

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Authors

JZJingxin ZhangWZWu ZhouYLYuancheng Liu

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Overview

Analysis shows TRIM6 correlates with immune cell infiltration and influences outcomes in AML, suggesting therapeutic potential.

Key Points

  • Low expression of TRIM6 predicts poor prognosis in acute myeloid leukemia patients with significant immune infiltration.
  • Kaplan-Meier and Cox regression models indicated that lower TRIM6 levels correlate with adverse outcomes in AML.
  • CIBERSORT analysis revealed higher levels of monocytes and M2 macrophages in patients with low TRIM6 expression.
  • TRIM6 expression engages the PI3K/AKT signaling pathway, highlighting its role in AML progression and immune response.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d435dd713b0b5dfea7569dhttps://doi.org/10.1371/journal.pone.0329560
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Study of PI3/AKT signaling pathway role in Acute myeloid Leukemia through assessment of long non-coding RNAs, GAS6-AS1 and TINCR expression2025
  2. 2Identification and validation of three tumor suppressors associated with the immune response of acute myeloid leukemia2025
  3. 3TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity2025
  4. 4Super-enhancer-mediated regulation of CD38 inducibility in multiple myeloma via the MAF/TRIM47/RARα axis2025
  5. 5Construction of a prognostic risk model for acute myeloid leukemia based on exosomal genes and analysis of immune microenvironment characteristics2025 · 4 citations