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April 1, 2025The Egyptian Journal of Haematology

Study of PI3/AKT signaling pathway role in Acute myeloid Leukemia through assessment of long non-coding RNAs, GAS6-AS1 and TINCR expression

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Authors

NTNourane TawfikNENermeen Eldabah

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Overview

Assessment reveals that GAS6-AS1 may serve as a diagnostic marker in acute myeloid leukemia, indicating its role in drug resistance.

Key Points

  • GAS6-AS1 overexpression correlates with acute myeloid leukemia prognosis, improving treatment outcomes in later stages.
  • Receiver operating characteristic analysis shows sensitivity of 70% and specificity of 92% for GAS6-AS1 in identifying AML cases.
  • Observational study involving 50 AML patients and 50 controls examined long non-coding RNAs' effects on the PI3K/AKT signaling pathway.
  • Results highlight the limited role of TINCR in acute myeloid leukemia, suggesting it’s not a viable therapeutic target.

Cite This Study

Tawfik et al. (2025) studied this question.

synapsesocial.com/papers/68af75207567bf4f94fee93ahttps://doi.org/10.4103/ejh.ejh_90_24
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