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August 15, 2025Journal of Experimental & Clinical Cancer ResearchOpen Access

TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

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Authors

YNYinan NiuCDChen DingQWQuansheng Wang

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Overview

Ablating TRIM6 improves antitumor immunity and response to anti-PD-L1 therapy in MSS gastric cancer, highlighting novel pathways.

Key Points

  • TRIM6 ablation enhances CD8+ T lymphocyte infiltration in MSS gastric tumors, boosting antitumor immunity and therapeutic efficacy.
  • Hypermethylation-mediated TRIM6 downregulation distinguishes microsatellite stable gastric cancers from MSI-H, leading to immune resistance.
  • Analysis utilized flow cytometry, RNA sequencing, and ubiquitination assays to explore the cGAS-STING pathway's role in immune responses.
  • The findings suggest TRIM6 as a promising biomarker and therapeutic target for overcoming immunotherapy resistance in gastric cancer.

Cite This Study

Niu et al. (2025) studied this question.

synapsesocial.com/papers/68af2b68cf1dd9ea359e4cffhttps://doi.org/10.1186/s13046-025-03513-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic potential of TRIM family proteins in gastric cancer: from signaling pathway regulation to precision targeting strategies2025
  2. 2TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration2025 · 1 citations
  3. 3Identification of a stromal immunosuppressive barrier orchestrated by SPP1+/C1QC+ macrophages and CD8+ exhausted T cells driving gastric cancer immunotherapy resistance2025
  4. 4Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity2025
  5. 5Tumor-derived PRMT1 suppresses macrophage antitumor activity by inhibiting cGAS/STING signaling in gastric cancer cells2025