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September 17, 2025Frontiers in GeneticsOpen Access

Identification and validation of three tumor suppressors associated with the immune response of acute myeloid leukemia

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Authors

YPYueyuan PanGWGuo-Cai WuCLChenchen Liu

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Overview

Research reveals three tumor suppressors related to immune response in acute myeloid leukemia, suggesting diagnostic potential.

Key Points

  • Three hub genes, CCR7, SLC16A6, and MS4A1, were identified as key tumor suppressors in acute myeloid leukemia.
  • The study found an imbalanced immune microenvironment in acute myeloid leukemia, affecting patient outcomes.
  • Differential analysis revealed several genes linked to acute myeloid leukemia, with significant implications for treatment.
  • The research utilized methods like ROC analysis and WGCNA to validate hub genes' predictive power for patient prognosis.

Cite This Study

Pan et al. (2025) studied this question.

synapsesocial.com/papers/68d42f63713b0b5dfea70c31https://doi.org/10.3389/fgene.2025.1652142
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