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September 18, 2025Journal of GastroenterologyOpen Access

Ferroptosis: biology and role in liver disease

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Authors

KHKeisuke HinoSNSohji NishinaIYIzumi Yanatori

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Overview

Review highlights ferroptosis mechanisms in liver disease, indicating potential therapeutic targets.

Key Points

  • Ferroptosis serves as a critical mechanism in liver injury and disease progression, impacting treatment outcomes.
  • Iron metabolism and lipid peroxidation are vital in determining liver cell susceptibility to ferroptosis.
  • Antioxidant pathways play a crucial role in regulating ferroptosis and protecting against liver damage.
  • Targeting ferroptosis shows promise for therapeutic strategies in various liver diseases.

Cite This Study

Hino et al. (2025) studied this question.

synapsesocial.com/papers/68d435cf713b0b5dfea74f4ehttps://doi.org/10.1007/s00535-025-02300-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Ferroptosis and Its Role in Disease Development2025 · 30 citations
  2. 2Ferroptosis as a Form of Cell Death—Medical Importance and Pharmacological Implications2025 · 9 citations
  3. 3Ferroptosis and Metabolic Dysregulation: Emerging Chemical Targets in Cancer and Infection2025 · 22 citations
  4. 4Ferroptosis inhibitors: mechanisms of action and therapeutic potential2025 · 34 citations
  5. 5Ferroptosis in cancer: revealing the multifaceted functions of mitochondria2025