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December 20, 2025Cellular and Molecular Life SciencesOpen Access

Ferroptosis inhibitors: mechanisms of action and therapeutic potential

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Authors

KDKun DuoXFXiaona FengXTXiaofang Tian

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Overview

This review uncovers therapeutic applications of ferroptosis inhibitors acting through pathways like lipid peroxidation and iron metabolism.

Key Points

  • The review aims to clarify the mechanisms of ferroptosis and the potential of its inhibitors in therapy.
  • Systematic exploration of ferroptosis mechanisms and defenses.
  • Discussion of small-molecule inhibitors targeting ferroptosis.
  • Analysis of pharmacological strategies for therapeutic applications.
  • Identified key mechanisms include lipid peroxidation and iron metabolism in ferroptosis.
  • Highlighted endogenous defenses like the GPX4 axis and DHODH pathway.
  • Demonstrated potential of various inhibitors, including antioxidants and iron chelators.

Cite This Study

Duo et al. (2025) studied this question.

synapsesocial.com/papers/6945ea41742299010fff02e5https://doi.org/10.1007/s00018-025-05958-5
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