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September 16, 2025International Journal of Biological SciencesOpen Access

Mechanism of Ferroptosis and Its Role in Disease Development

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Authors

ZYZ. YeBXBin XieYTYongguang Tao

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Overview

Analysis of ferroptosis mechanisms shows its influence on disease development, highlighting key biochemical features.

Key Points

  • Ferroptosis leads to cell death through unique mechanisms involving lipid peroxidation and iron accumulation.
  • Iron ions catalyze the production of reactive oxygen species, which damage the phospholipid bilayer and result in cell death.
  • Research indicates a strong link between ferroptosis and various diseases, including nervous system diseases and tumors.
  • Regulating ferroptosis may offer new strategies for controlling disease progression, representing an emerging research focus.

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/68d4262e713b0b5dfea6bf02https://doi.org/10.7150/ijbs.102859
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