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July 19, 2025Cellular and Molecular Life SciencesOpen Access

Ferroptosis in cancer: revealing the multifaceted functions of mitochondria

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Authors

XDXinyi DingLCLei CuiYMYanjun Mi

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Overview

Review uncovers ferroptosis regulation mechanisms in cancer, highlighting mitochondria's role in overcoming drug resistance.

Key Points

  • Ferroptosis is a programmed cell death mechanism linked to cancer progression and often involves mitochondria.
  • Key regulatory pathways for ferroptosis include GSH-GPX4 and FSP1-CoQ10, which influence lipid peroxidation.
  • Mitochondria play a crucial role in supporting the processes that lead to ferroptosis, impacting cancer cell viability.
  • Targeting ferroptosis may provide a new therapeutic strategy to combat drug-resistant tumors in cancer patients.

Cite This Study

Ding et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccedfhttps://doi.org/10.1007/s00018-025-05812-8
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