Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 18, 2025Open Access

Cell-cycle dynamics of nascent transcription and mature RNA accumulation are concordant in normal fibroblasts

View Full Paper
Ask AI
Bookmark
Share

Authors

MGMelanie E. GucwaKIKohta Ikegami

Discussion

Loading...

Member takes

Overview

Observational analysis shows concordant nascent transcription and RNA accumulation in fibroblasts, suggesting a unified regulatory mechanism.

Key Points

  • Transcription and RNA accumulation dynamics are highly concordant in normal fibroblasts, indicating no traditional lag.
  • Strong concordance was observed, challenging the notion of a transcription-to-maturation lag usually seen in cancer cells.
  • Co-profiling of nascent and mature RNAs in human fibroblasts reveals insights into gene expression during the cell cycle.
  • Findings suggest that widespread transcription-to-maturation lag is not a general feature of human cells.

Cite This Study

Gucwa et al. (2025) studied this question.

synapsesocial.com/papers/68d434e3713b0b5dfea742eahttps://doi.org/10.1101/2025.09.12.675830
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell multiomics reveals the oscillatory dynamics of mRNA metabolism and chromatin accessibility during the cell cycle2025
  2. 2Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis2025
  3. 3Intergenic accumulation of RNAPII maintains the potential for swift transcriptional restart upon release from quiescence.2025
  4. 4Regulation of Transcriptional Bursting and Spatial Patterning in Early Drosophila Embryo Development2025
  5. 5Single-molecule imaging of transcription dynamics, RNA localization and fate in human T cells2025