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August 14, 2025

Intergenic accumulation of RNAPII maintains the potential for swift transcriptional restart upon release from quiescence.

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Authors

MPM. PerezGLGertjan LaenenILIsabelle Loı̈odice

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Overview

Analysis shows transcription restarts rapidly in quiescent yeast cells, indicating RNAPII plays a key role in this process.

Key Points

  • Transcription restarts quickly after quiescence, driven by RNAPII accumulation, pointing to cellular adaptability.
  • Genome-wide analysis reveals 3% of genes remain active during quiescence, enriching known active transcription patterns.
  • Synchronized assessments of transcription and telomere clustering demonstrate their independence in quiescent yeast.
  • Single-cell RNA-seq reveals that specific RNAPII distribution during quiescence predicts robust transcription post-refeeding.

Cite This Study

Perez et al. (2025) studied this question.

synapsesocial.com/papers/689fc962e46e096235ce1bcchttps://doi.org/10.1101/gr.279874.124
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Guardians of silence: transcriptional networks in T cell quiescence2025
  2. 2"Genome Stability under Silence: DNA Repair Networks in Quiescent Fission Yeast"2025
  3. 3The environmental stress response controls the biophysical properties of the cytoplasm and is critical for survival in quiescence2025
  4. 4Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation2025
  5. 5Disruption of nucleolar integrity triggers cellular quiescence through organelle rewiring and secretion2025