September 18, 2025MEDISAINSOpen Access

Temporal changes in blood glucose levels and organ histopathology in alloxan-induced diabetic rats

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Authors

ARAyeshah Augusta Rosdah ANAmanda Natasha SFSoilia Fertilita

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Overview

Observational analysis found severe hyperglycemia and organ pathology in alloxan-induced diabetic rats, suggesting a potential link between glucose levels and multi-organ damage.

Key Points

Diabetic rats exhibited sustained hyperglycemia exceeding 400 mg/dL, with significant peaks at 508.25 mg/dL and 544 mg/dL over 14 and 30 days respectively.
Histopathological evaluations indicated substantial pancreatic damage, including islet distortion and cellular degeneration, alongside liver and kidney abnormalities.
The study recorded a 42.9% dropout rate due to hypoglycemic episodes occurring shortly after alloxan administration.
Tissue analysis demonstrated progressive damage in the liver and kidneys, with increased sinusoidal congestion and glomerular shrinkage observed over time.

Cite This Study

Rosdah et al. (2025) studied this question.

synapsesocial.com/papers/68d433b0713b0b5dfea7362a https://doi.org/10.30595/medisains.v23i2.27022

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September 18, 2025MEDISAINSOpen Access

Temporal changes in blood glucose levels and organ histopathology in alloxan-induced diabetic rats

View Full Paper

Ask AI

Bookmark

Authors

ARAyeshah Augusta Rosdah ANAmanda Natasha SFSoilia Fertilita

Discussion

Member takes

Overview

Observational analysis found severe hyperglycemia and organ pathology in alloxan-induced diabetic rats, suggesting a potential link between glucose levels and multi-organ damage.

Key Points

Diabetic rats exhibited sustained hyperglycemia exceeding 400 mg/dL, with significant peaks at 508.25 mg/dL and 544 mg/dL over 14 and 30 days respectively.
Histopathological evaluations indicated substantial pancreatic damage, including islet distortion and cellular degeneration, alongside liver and kidney abnormalities.
The study recorded a 42.9% dropout rate due to hypoglycemic episodes occurring shortly after alloxan administration.
Tissue analysis demonstrated progressive damage in the liver and kidneys, with increased sinusoidal congestion and glomerular shrinkage observed over time.

Cite This Study

Rosdah et al. (2025) studied this question.

synapsesocial.com/papers/68d433b0713b0b5dfea7362a https://doi.org/10.30595/medisains.v23i2.27022

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