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September 10, 2025Scientific ReportsOpen Access

Endothelial function can be modulated by acute hyperglycemia

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Authors

HQHassanain QambariPYPaula K. YuCBChandrakumar Balaratnasingam

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Overview

Research demonstrates that acute hyperglycemia alters endothelial responses, highlighting potential microvascular dysfunction in diabetes.

Key Points

  • Endothelial function improved after short-term exposure to acute hyperglycemia in diabetic eyes.
  • Acetylcholine-induced vasodilation responses were enhanced in diabetic rats, especially after less than 2 hours of high glucose.
  • In the 4-week diabetic group, endothelial responses remained elevated, indicating potential irreversible dysfunction.
  • Analysis revealed increases in pericyte distribution and endothelial nitric oxide synthase in early-stage diabetes.

Cite This Study

Qambari et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4833https://doi.org/10.1038/s41598-025-12612-4
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