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August 16, 2025BIOMED natural and applied scienceOpen Access

Effect of ground coffee beans extract on the histological structures of alloxan induced diabetes female albino rats

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Authors

KEKelechi Purity EzennubiaMJMike-Anosike E Ofoegbu JTATemilade R Adeniran

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Overview

Experimental study reveals green coffee bean extract improves histological structures in diabetic female rats, suggesting its potential as a treatment adjunct.

Key Points

  • The 400 mg/kg GCBE treatment significantly improved tissue integrity compared to diabetic controls, reducing kidney glomerulosclerosis and liver fat accumulation.
  • Histological scoring revealed the 400 mg/kg GCBE group had a kidney score of 1.2±0.3 versus 3.8±0.5 for the diabetic control, highlighting its effectiveness.
  • Comparison with metformin also showed kidney improvement but limited benefits for heart and liver tissues, indicating a need for alternative therapies.
  • Green coffee bean extract's phytochemicals, like chlorogenic acids, suggest potential for reducing oxidative stress in diabetic complications.

Cite This Study

Ezennubia et al. (2025) studied this question.

synapsesocial.com/papers/68c235fdb210217d64772e99https://doi.org/10.53858/bnas05030116
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Also Consider

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  1. 1Effect of Giving Ethanol Extract of Robusta Coffee Beans (Coffea canephora Pierre ex A. Froehner) Based on Immunohistochemical Examination of GLUT-4 Protein Expression in White Rats (Rattus norvegicus) Model of Diabetes Mellitus2025
  2. 2HISTOLOGICAL EFFECT OF ANTIDIABETIC HERBAL TEA ON THE KIDNEY OF ALBINO RATS INDUCED WITH ALLOXAN (DIABETES)2025
  3. 3Histomorphological Changes of Heart and Kidney of An Alloxan Induced Wister Rats Treated with Gongronema Latifolium Leaf Extract2024
  4. 4Effect of combined extract of leaves of Medicago sativum and seeds of Garcinia kola on biochemical indices of alloxan-induced diabetic rats.2025
  5. 5Beetroot Extract and Its Anti-Diabetic: Neuroprotective Effect in the Frontal Cortex and Cerebellar Cortex of Diabetic Wistar Rats2025