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September 18, 2025Microbiology SpectrumOpen Access

Molecular insights into the persistence and co-occurrence of two different carbapenem-resistant Pseudomonas aeruginosa lineages within a hospital setting

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Authors

XLXinran LiKWKaiying WangJCJiali Chen

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Overview

Analysis reveals resistance profiles and molecular epidemiology of CRPA in hospital isolates, indicating potential outbreaks.

Key Points

  • High prevalence of carbapenem-resistant Pseudomonas aeruginosa isolates indicates serious health risks.
  • Among 137 CRPA isolates, 41.6% were from respiratory specimens, suggesting common infection routes.
  • Whole-genome sequencing and bioinformatic analyses identified 54 sequence types and significant antibiotic resistance traits.
  • Findings highlight urgent need for strategies to manage CRPA and prevent further healthcare-associated infections.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d433b0713b0b5dfea733fbhttps://doi.org/10.1128/spectrum.00433-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antimicrobial Resistance Mechanisms in Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Clinical Strains Isolated in Shanghai, China2025
  2. 2Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Isolates from a Multicenter Study in Korea2025 · 4 citations
  3. 3Carbapenem Resistance among &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; isolated from Clinical Samples with a Special Reference to Colistin Resistance2025
  4. 4Co-occurrence of mcr-1 and mcr-3 mobilized colistin resistance genes among carbapenem-resistant Pseudomonas aeruginosa in Iran2025
  5. 5Trends in prevalence and antibiotic susceptibility of multidrugs-resistant Carbapenem-Resistant <i>Acinetobacter baumannii</i> (CRAb) and carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CRPa) in blood culture2025