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September 5, 2025Polish Journal of MicrobiologyOpen Access

Antimicrobial Resistance Mechanisms in Carbapenem-Resistant Pseudomonas aeruginosa Clinical Strains Isolated in Shanghai, China

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Authors

KZKeying ZhuSLSu‐Ting T. LiZGZiyan Guo

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Overview

Observational analysis of resistance mechanisms in carbapenem-resistant Pseudomonas aeruginosa, revealing significant genetic diversity.

Key Points

  • High expression of mexY correlates with increased resistance rates in carbapenem-resistant Pseudomonas aeruginosa isolates.
  • Analysis identified various β-lactamase genes, including bla GES-5 and bla OXA-50-like, contributing to resistance mechanisms.
  • Whole genome sequencing unveiled a new gene cassette array associated with antimicrobial resistance in clinical isolates.
  • Common sequence types ST235 and ST270 dominated among 40 studied carbapenem-resistant strains from Shanghai.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d421https://doi.org/10.33073/pjm-2025-022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bla producing Pseudomonas aeruginosa ST235 is involved in resistance to different β-lactams2025
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  3. 3Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Isolates from a Multicenter Study in Korea2025 · 4 citations
  4. 4ANTIMICROBIAL RESISTANCE PATTERNS AND PHENOTYPIC CARBAPENEMASE DETECTION IN CLINICAL PSEUDOMONAS AERUGINOSA ISOLATES2025
  5. 5Carbapenem Resistance among &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; isolated from Clinical Samples with a Special Reference to Colistin Resistance2025