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September 10, 2025Journal of Pain ResearchOpen Access

The Analgesic Effect of NLRP3 Inflammasome in the Relief of Inflammatory Pain by Electroacupuncture: A Systematic Review and Meta-Analysis of Animal Studies

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Authors

RSRuisi SuZWZhefeng WangGZGuodong Zhang

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Overview

Systematic review and meta-analysis shows electroacupuncture reduces inflammatory cytokines in animal studies, suggesting NLRP3 involvement.

Key Points

  • Electroacupuncture significantly increases heat and mechanical pain thresholds in inflammatory pain models.
  • Meta-analysis reports a reduction in pro-inflammatory cytokines and increases in anti-inflammatory cytokines through electroacupuncture.
  • Animal studies indicate electroacupuncture modulates the NLRP3 inflammasome and related signaling pathways.
  • Findings support the potential of electroacupuncture to reduce reliance on traditional analgesic medications.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a6090https://doi.org/10.2147/jpr.s534757
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electroacupuncture Alleviates Neuropathic Pain by Inhibiting Spinal CCL2-Driven Microglial Activation2025
  2. 2Effect of electroacupuncture on interleukin-6 and procalcitonin expression in the astrocytes and neurons of the spinal cord dorsal horn in a rat model of incisional pain2025
  3. 3[Study on the analgesic effect of electroacupuncture at different intensities on the primary input level in mice with inflammatory muscle pain based on 2025 · 1 citations
  4. 4Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway and microglial suppression in the chronic constriction injury rat model of neuropathic pain2025
  5. 5Efficacy, Safety and Mechanisms of Acupuncture and Electroacupuncture for Pain: A Narrative Review2025