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September 16, 2025Advanced ScienceOpen Access

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

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Authors

HLHuanyi LiuShaanxi Normal UniversityHWHao WuZZZiyu ZhangCentral South University

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Implication

This observational analysis reveals SELENOT suppression impacts muscle atrophy in chickens, suggesting new therapeutic targets.

Key Points

  • SELENOT deficiency leads to increased oxidative stress and triggers muscle atrophy through disulfidase pathways.
  • The study found that mtROS overproduction and NADPH disruption are critical in regulating muscle integrity during selenium deficiency.
  • TEMPO-mediated mtROS inhibition partially rescues muscle atrophy, indicating potential therapeutic strategies for selenium deficiency.
  • SELENOT overexpression can alleviate muscle atrophy by correcting redox imbalance and NADPH dysfunction.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d4232f713b0b5dfea6b552https://doi.org/10.1002/advs.202507283
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