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September 10, 2025Journal of Microbiology Immunology and InfectionOpen Access

Microbiota-mediated metabolic alterations reveal bidirectional regulation of the gut-nose axis in mice with allergic rhinitis

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Authors

LDLin DongCTChen TianFLFen Li

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Overview

Investigation shows altered microbiota and metabolites impact allergic rhinitis in mice, suggesting a gut-nasal axis role.

Key Points

  • Allergic rhinitis mice exhibited aggravated nasal symptoms and significant microbiota and metabolite changes.
  • Correlation analysis indicated bidirectional influence between gut microbes and nasal metabolites.
  • Mendelian randomization demonstrated a causal relationship between gut microbiota and allergic rhinitis.
  • Altered expression of ZO-1 and Claudin 1 protein in nasal mucosa implies structural disruption in AR mice.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c2443bb210217d647aa2e8https://doi.org/10.1016/j.jmii.2025.08.021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered Nasal Microbiota-Metabolome Interactions in Allergic Rhinitis: Implications for Inflammatory Dysregulation2025
  2. 2Nasal Microbiota as a Potential Therapeutic Target for Allergic Rhinitis: An Emerging Perspective2025
  3. 3Integrative metagenomic and metabolomic analysis reveals a gut microbiota-metabolite-immune axis in pediatric allergic rhinitis with functional constipation2026
  4. 4Integrative Multi-Omics Analysis Characterizes Immune Dysregulation and Altered CD4+ Central Memory T-Cell Abundance in Allergic Rhinitis2026 · 1 citations
  5. 5The causal impact of gut microbiota on allergic rhinitis mediated by cerebrospinal fluid metabolites: A study based on Mendelian randomization and mediation analysis2026