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September 16, 2025Open Access

Diagnostic Accuracy and Yield of Determine Urine TB LF-LAM for Detecting Tuberculosis Among Adults and Children with Advanced HIV Disease in Nigeria.

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Authors

JNJustin Onyebuchi NwofeLMLaura MadukajiDODaniel Chinenyeike Offie

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Overview

Cross-sectional study shows improved diagnostic yield of LF-LAM for detecting TB in HIV patients, highlighting its role in routine testing.

Key Points

  • LF-LAM achieved a diagnostic yield of 30.4% among AHD patients tested with urine samples.
  • Among 5,212 LF-LAM positive cases, 2,074 were missed by traditional WHO screening methods.
  • The incremental yield of LF-LAM over GeneXpert was 39%, demonstrating its added value in diagnosis.
  • Routine integration of LF-LAM into HIV programs can significantly reduce TB mortality among high-risk patients.

Cite This Study

Nwofe et al. (2025) studied this question.

synapsesocial.com/papers/68d42328713b0b5dfea6afa9https://doi.org/10.1101/2025.09.13.25335679
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The use of lateral flow lipoarabinomannan for diagnosis of TB in advanced HIV disease in Abia State, Nigeria2025
  2. 2Combination of urinary lipoarabinomannan assay and GeneXpert MTB/RIF ultra enhances tuberculosis detection among HIV-infected individuals2025
  3. 3Lateral flow urine lipoarabinomannan assay for tuberculosis diagnosis in HIV-positive inpatients and outpatients2025
  4. 4Uptake and disparities in tuberculosis screening using urine-lipoarabinomannan among patients with advanced human immunodeficiency virus-disease in Africa: A systematic review2025
  5. 5Value of urinary lipoarabinomannan levels for tuberculosis diagnosis and monitoring of therapy2025