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August 20, 2025Frontiers in MicrobiologyOpen Access

Value of urinary lipoarabinomannan levels for tuberculosis diagnosis and monitoring of therapy

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Authors

YXYiqun XiongZSZhihong ShenBDBo Dong

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Overview

Prospective cohort study assesses urinary lipoarabinomannan's diagnostic sensitivity and monitoring in tuberculosis, suggesting clinical utility for personalized treatment.

Key Points

  • Urinary lipoarabinomannan showed sensitivity of 58.75% for tuberculosis diagnosis, outperforming Acid-fast bacilli smear.
  • In monitoring, LAM maintained positivity in 11.54–51.72% of patients by week 12, versus under 15% for other tests.
  • A combined model of baseline PreLAM and ΔLAM achieved an AUC of 0.871–0.943 for predicting treatment response.
  • LAM serves as a dual-role biomarker, highlighting its potential in improving tuberculosis treatment management.

Cite This Study

Xiong et al. (2025) studied this question.

synapsesocial.com/papers/68af4093cf1dd9ea359ec528https://doi.org/10.3389/fmicb.2025.1653031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lateral flow urine lipoarabinomannan assay for tuberculosis diagnosis in HIV-positive inpatients and outpatients2025 · 2 citations
  2. 2The use of urinary lateral-flow lipoarabinomannan assays for TB diagnosis in children2026
  3. 3Combination of urinary lipoarabinomannan assay and GeneXpert MTB/RIF ultra enhances tuberculosis detection among HIV-infected individuals2025
  4. 4Diagnostic Accuracy and Yield of Determine Urine TB LF-LAM® for Detecting Tuberculosis Among Adults and Children with Advanced HIV Disease in Nigeria2025
  5. 5The Utility of C-reactive Protein Levels and Tb Lam Test as Diagnostic Tools for Tuberculosis among HIV Art Clients, attending Fort Portal Regional -Referral Hospital-Uganda2025