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September 16, 2025Indian Journal of NephrologyOpen Access

Unravelling the Multifactorial Pathogenesis and Immune Cell Infiltrates in Transplant Glomerulopathy

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Authors

PGP. GopalakrishnaASAravind SekarRNRitambhra Nada

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Overview

Analysis of immune cell infiltrates reveals their role in transplant glomerulopathy's complex mechanisms, indicating potential interventions for chronic allograft injury.

Key Points

  • Transplant glomerulopathy primarily arises from multifactorial mechanisms, impacting graft survival.
  • Immune cell types such as M2 macrophages and CD8+ T-cells were notably elevated in affected regions.
  • Data was gathered through dual- and single-color immunohistochemistry on renal allograft biopsies.
  • Findings suggest targeting specific immune cells might improve chronic allograft injury outcomes.

Cite This Study

Gopalakrishna et al. (2025) studied this question.

synapsesocial.com/papers/68d4218f713b0b5dfea69a02https://doi.org/10.25259/ijn_74_2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibody-Mediated Rejection in Kidney Transplantation: Immunopathogenesis, Innate–Adaptive Crosstalk, and Therapeutic Advances2025
  2. 2Spatial transcriptomics reveals distinct role of monocytes/macrophages with high FCGR3A expression in kidney transplant rejections2025
  3. 3Recurrent immunotactoid glomerulopathy in a kidney transplant recipient: Case report2025
  4. 4Recurrence of Glomerular Diseases (GN) After Kidney Transplantation: A Narrative Review2025
  5. 5Renal Involvement in Chronic Graft-Versus-Host Disease.2025