Review highlights the role of donor-specific antibodies and innate-adaptive crosstalk in kidney transplantation, implying a need for improved diagnostic strategies.
Key Points
Antibody-mediated rejection notably affects graft survival, often leading to dysfunction or failure.
Recent advances highlight the role of genomic profiling in understanding the underlying mechanisms of rejection.
Timely intervention during routine monitoring in subclinical cases of rejection may enhance long-term graft outcomes.
An integrated approach combining mechanistic insights with clinical application is crucial for improving diagnostic precision.