Spatial transcriptomics identifies unique features of monocytes/macrophages in active kidney transplant rejection, suggesting their critical roles.
Key Points
Monocytes/macrophages with high FCGR3A expression are implicated in acute and chronic kidney transplant rejection.
Transcriptomic analysis of kidney allografts reveals differences in gene expression among rejection types, with an emphasis on innate immune responses.
The study utilized spatial transcriptomics on FFPE biopsies to uncover cellular distributions linked to tissue pathology during rejection.
These insights support the hypothesis that targeting FCGR3A-expressing monocytes/macrophages may improve transplant outcomes.