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September 14, 2025Annals of Surgical OncologyOpen Access

Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery: A Large-Scale Exploratory Study

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Authors

TSTakuya SugimotoYYYukihiro YokoyamaYKYukiko Kado

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Overview

Exploratory study finds gut bacteria and lactic acid levels linked to infection risk after gastrointestinal cancer surgery.

Key Points

  • Higher fecal lactic acid concentrations are associated with increased postoperative infectious complications.
  • Patients with greater preoperative abundances of Akkermansia muciniphila and Lactococcus lactis had lower infection rates.
  • This study analyzed fecal samples using high-performance liquid chromatography and gene sequencing methods.
  • The findings highlight potential roles for gut microbiota in managing postoperative infection risks through preoperative assessments.

Cite This Study

Sugimoto et al. (2025) studied this question.

synapsesocial.com/papers/68d4203f713b0b5dfea68803https://doi.org/10.1245/s10434-025-18298-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Surgical and Perioperative Factors in Shaping Gut Microbiome Recovery After Colorectal Surgery2025 · 8 citations
  2. 2Integrated Public Health Evaluation of Gut Microbiota, Inflammatory Biomarkers, and Nutritional Status in Patients Undergoing Colorectal Cancer Surgery2023
  3. 3Postoperative gut dysbiosis and its clinical implications, with an emphasis on probiotic strategies in gastric cancer patients undergoing gastrectomy: a narrative review2025
  4. 4Perioperative changes in the microbiome during rectal cancer surgery: exploratory analysis of the National Institute for Health and Care Research (NIHR) IntAct trial2025
  5. 5Risk factors for postoperative abdominal infection of colorectal cancer: A systematic review based on the PRISMA guidelines2026