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September 5, 2025AntibioticsOpen Access

The Role of Surgical and Perioperative Factors in Shaping Gut Microbiome Recovery After Colorectal Surgery

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Authors

JKJulia KöhnATAlexander TroesterZZZachary Ziegert

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Overview

Observational analysis examines gut microbiome recovery in colorectal surgery patients, indicating significant impacts from surgical factors and bowel preparation.

Key Points

  • Postoperative gut microbiome recovery is significantly affected by surgical factors, particularly resection and bowel preparation.
  • Microbial diversity metrics showed significant variations, with alpha diversity returning by POD10 for colonoscopy patients and POD180 for others.
  • Surgical cohorts experienced substantial losses of beneficial bacteria, with resectional patients showing persistent pathogenic increases 6 months post-surgery.
  • Diagnosis had minimal long-term impact on microbiome recovery, though cancer patients exhibited more stability than those with diverticulitis.

Cite This Study

Köhn et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d647808e2https://doi.org/10.3390/antibiotics14090881
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